United Airlines Breaks Guitars Case Study Example | Topics and Well Written Essays - 1000 words

Joined Airlines Breaks Guitars - Case Study Example Issues The organization has a workforce of 50,000 representatives around the world (Deighton and Kornfeld). Regardless of the firm’s assets the organization has not had the option to successfully utilize its workforce to give brilliant client assistance to its customers. The absence of client assistance has developed and the firm has been losing customers because of its absence of care for the necessities of the clients of the organization. Dave Carroll made a sensible solicitation when his guitar was harmed because of the misusing of his property by the representatives of the organization. A second issue that must be considered by the organization is the way to actualize blow-back so as to stop the Dave Carrols occurrence to keep on heightening any further. The organization can't manage the cost of for this issue to keep on being in the predominant press for quite a long time or even years. The outcomes of the tune being a hit that waits into the mainstream society for a significant stretch of time would be destroying for United Airlines. Elective arrangements The firm presently faces a significant issue because of the Dave Carroll circumstance. An approach to confront the issue and discover a goals to wipe out the overflow impact the video can have in the long haul is by arriving at a private settlement with Dave Carroll to remunerate him for corrective harms. The premise of the understanding would include Dave taking the video off YouTube and different destinations and for him to make an open declaration that the issue was settled with United Airlines and he was happy with their last goals. The organization would pay Dave Carrols a singular amount installment of $250,000 to $500,000. A second elective answer for manage the issue is to apply evasion. Shirking includes disregarding the issue by imagining an issue doesn't exist (Schermerhorn and Hunt and Osborn). The organization would let time fix the issue as individuals forget about it and proceed onward the following bit of news. This elective arrangement can be applied at an exceptiona lly minimal effort to the organization. The hazard related with the arrangement is that YouTube fills in as a video database. On the off chance that the firm is unfortunate the notoriety of the melody may wait for an extensive stretch of time. A third elective arrangement is to dismiss the momentary issue related with the Carroll episode and to execute an answer that will keep the organization from confronting comparative issues later on. The firm needs to start to pick up the trust of its clients by definitely expanding the degree of client care. First off the strategy of taking out every single free nibble to clients must be turned around. Individuals get restless during flights and offering a light bite for nothing out of pocket is a path for the client to realize that the organization cares. The firm would actualize new principles and rules conventions to manage harm products episodes. The arrangement of detailing the harm inside 24 hours will be changed to 30 days to permit ade quate time for the voyagers to complete their relax and get back home to document out the grumbling. A fourth elective arrangement is for the organization to make another protection administration to secure their baggage resources. The protection could be buy to guarantee things at various worth ranges, for example, $1-500, $501-1000, and $1001-$10,000. The expense of the protection would be paid for when the clients buy their tickets or at the aircrafts before the flight. On the off chance that the client bought the protection with the tickets they would got a 10% in the acquisition of the protection. This arrangement would give an approach to fulfill the

An Analysis of the Poem A Prayer for My Daughter by William Butler Yeat

A Prayer for My Daughter is a sonnet composed by William Butler Yeats in 1919. This sonnet is a supplication like sonnet. Furthermore, it by and large educates regarding the artist's thoughts regarding his little girl who is resting simultaneously while the sonnet is being told. All through the sonnet Yeats reflects how he needs his little girl's future to be. This paper will examine the sonnet in three areas: 1-What does this sonnet mean?, 2-The graceful gadgets, symbolism, rhyming, sayings, utilized in the sonnet and mind-set, lingual authority, language, and the structure of the sonnet, 3-An exposition in a women's activist perspective titled What does the artist need his little girl to become? . 1-WHAT DOES THIS POEM MEAN? The writer is watching his newborn child little girl rest. In the primary verse he begins with portraying the setting of the sonnet. It is blustery outside, there is a sort of dull and desolate climate and he appeals to God for her. Also, he says that he has agony in his brain and we will comprehend that what unhappiness is that in his psyche. In the second verse the writer portrays the things while he was appealing to God for his little girl. He strolls for an hour and notification the ocean wind shout upon the pinnacle, under the curves of the scaffold, in the elms over the overflowed stream. They likely speak to the longing for the people and they are conclusive. They are about the current things and they square individuals from contemplating the future occasions. The last four lines of the subsequent refrain obviously clarify this thought: Envisioning in energized dream That the future years had come, Moving to a furious drum, Out of the deadly blamelessness of the ocean. In the third refrain he appeals to God for her excellence, yet not all that much. He thinks about the excellence as a definitive component for picking the ideal individual to mama... ... portions of the perfect lady he has in his psyche or its alternate extremes. He bolsters that a lady ought to be a thriving concealed tree, who isn't notable however excellent. She shouldn't be anything besides cheerful. Innocence is excellent in ladies, that is the reason if his girl keeps her blamelessness inside and don't mishandle it, she won't be influenced by the wind. He imagines that an excessive amount of magnificence twists ladies, and makes them decimate the endowments that are given by Horn of Plenty in this way he needs his little girl to utilize the blessings shrewdly and appropriately. Also, he needs his girl to gain proficiency with the way that hearts are earned, and the men, who are deluded by just magnificence, will see their slip-up later. He needs her little girl not to have solid assessments like scorn, since he feels that disdain is the most noticeably awful thing on the planet. He trusts she will wed, and her home will be loaded with customs.

Dont Go Chasing Waterfalls How to Choose Your Safety Schools, feat. Wisdom from TLC TKG

Don’t Go Chasing Waterfalls How to Choose Your Safety Schools, feat. Wisdom from TLC It’s time to pick your safety schools. And while you’ve tried different ways to imagine that you’re not going to have to resort to going there, it’s all the same: your test scores are what they are and each school has an average range. The good news is, there are THOUSANDS of schools in this country. There are bound to be three to five you don’t hate.Thought That They Would Never Do Me Wrong  So, we’ve accepted the fact that you can probably come up with at least a few safety schools that don’t suck to you. Great! You’re halfway there. Now, the next step is figuring out which of those actually look pretty good. We wish it weren’t so, but the hard truth is that a “safety” is not a guarantee. In fact, it’s often less of a guarantee than a target. That’s not because you’re a scrub. (You’re not). It’s because schools often know that they’re your safety. So, if you fall into the 75th percentile of scores (which is what we at TKG consider to be a safety), schools who are worried about their yield rates would sometimes rather offer admission to a candidate they think is more likely to attend.Your Outsides Are Cool, Your Insides Are Blue…But You Still Need to Pick a SchoolOnce you’ve chosen the schools for which you fall into the right percentile, it’s time to think about the criteria you’d like each school to meet. Consider that for this exercise, you should have it your way or nothing at all. The two most important factors are personality and programs. Consider what kind of environment you’d like to see in a school. Size, social life, extra-curriculars, and distance from home should all be factors in creating your list. Then, focus on the kinds of classes and majors they offer.Picking the right safety schools for you are not only important as a backup, but as a potential first-choice, too. Many schools offer merit-based scholarships to highly-qualified students.   While we are not a financial-aid company and are not necess arily experts in the subject, a number of our clients (those who don’t qualify as being need-based) are getting merit-based scholarships. No matter how wealthy you are, college is really expensive. If you get any money your way, that’s something to consider, so choose your safeties wisely.Want to make sure you have a diverse and solid list of schools on your application list? Reach out to us. We can help you identify the right places for you.

International Student Identity Essay - 2118 Words

International student identity and its impact to the future Identity is sort of behaviour that can be symbolized by individual or communities by showing how they interact to each other and how they represent their culture of origin. These essay will discuss and analyse some theories of indentity through culture and languange views and then show the reader how these lense might influence international student identity. The structure of essay will be organised as follows; First of all, introduction will explain an overview of it. This is followed by describing the theory of identity. The next section is about discussion of identity by using culture and language focuses. Furthermore, writer will explain the impact of new culture and†¦show more content†¦Moreover, it represents the identity of a society (Miller 2000, 69). For example, International students from Indonesia, Middle East countries, or China, will speak by using their native language when they interact to student from same country. Indonesian language, Arabic language, Manda rin or Cantonese languages are their identity. People might know who they are by listening to their conversation. Language and identity can not be separated. Scholars argue that language use and identity is inherent with social practices and membership (Miller 2000, 69). He also affirms that self-representation is a product of language use and identity (Miller 2000, 69). How person speaks, what type of vocabularies, represent the identity of the speaker. For instance, a truck driver will not use same language as a Professor use, and a postgraduate student has different style of language that high school student does. Even though they have same mother tongue, such as English, they speak differently because they come from different society. Their identity shows what and how they differ. International Student Identity People who pursue their study to overseas’ university will have new identity as international student. They become member of student society. During study, each individual enacts its duty as student (Fearon 1999, 19). A student can be seen by another member of society as collegeShow MoreRelatedRace And Ethnic Identity : Racial Identity1000 Words   |  4 Pages1.0 RACE AND ETHNIC IDENTITY In many perspectives, racial identities mean the differences in appearances of individuals especially with regards to the color of skin. Racial identities are mostly determined genetically or biologically. This includes traits like hair, bone structure color of the eyes etc. In recent times the biological determination of race has been disputed by social scientists who also propounds that races have more fluid social contexts. On the other hand, ethnicity encompassesRead MoreThe Social Needs For Students Intellectual Development More Than Their Personal Growth Essay1470 Words   |  6 PagesIntroduction: Background Generally speaking, universities place emphasis on students’ intellectual development more than their personal growth. Nevertheless, many students experience college life stressful. College students often find themselves feeling isolated as they begin their lives on a university campus (Corey, Corey, Corey, 2014). Therefore, their social needs in addition to their academic needs must be addressed (see Corey, et al., 2014; Ramsay, Jones, Barker, 2007). DevelopmentallyRead MoreStudent Office Should Be An Inclusive And Welcoming Community Essay1431 Words   |  6 PagesUW-Madison is a place of diversity, fill with many different people from all kinds of background. International students play a prominent role in the diversity of the community. Walking in the street of campus, I find individuals who are Chinese, Korean, Japanese, Mexican, African American, Muslim, Caucasian and much more. In fact, I do not even know the racial identity of some students I met. Although, at a quick glance, the community seem well diverse, however, there are still barriers that preventRead MoreForeign Students And Other Socio Cultural Contexts Essay1363 Words   |  6 PagesAt present there is a growing volume of students who migrate from one Culture to another, which represents a phenomenon that requires understanding the process Of adaptation or acculturation to the different socio-cultural contexts. I will begin by defining the term foreign students, it refers to Individuals who reside voluntarily and temporarily in a country that is not their own in order to participate in the international educational exchange, intending to Return to their country of originRead MoreLanguage And Thinking Of The Esl Class Being Offered This Fall952 Words   |  4 Pagescomment, I had to explain and correct many misconceptions to my classmates: 1. I was not an international student 2. ESL was a class I had taken in middle school 3. My accent did not make me less competent or diminished my ability to understand them. It was also the first of many classes where I have heard such offensive statements targeting my background. Unfortunately, many people of color and international students have a similar experience to mine. While those statements make many feel uncomfortableRead MoreThe Middle State University ( Mtsu )855 Words   |  4 Pagesthe largest universities in Tennessee; however, they do not offer enough housing to provide for all of their students. As a result, students are expected to find their own housing off-campus. Hence, students must live in off-campus apartment complexes that are expensive, too far away, and difficult for young students to rent. While there are some benefits to off-campus housing, students face many problems in securing these types of housing situations. The prices of off-campus housing are high andRead MoreAnalysis of Some of the Benefits of Study Abroad Essay1538 Words   |  7 Pagesabout the Middle East. The students from Europe, especially from America, are moving towards the Middle East Universities for education (Vesely, 2005). They want to now the culture and language changes in the Middle East universities, especially in Jordan. Benefits of the Study Abroad: There are a number of education organizations in the world that working for the student exchange programs to enhance the harmony, peace and communication among the different people. The students that are above than 20Read MoreAcademic Achievements And Social Adjustments Among International Students1665 Words   |  7 PagesInternational students face a variety of adjustments while studying in the United States. Researchers have provided an understanding of the kinds of adjustments international students have while adapting to university life, and one of the most discussed adjustments international student faces is with social adjustment (Andrade, 2014). Social adjustment is an effort made by an individual to cope with standards, values and needs of a society to be accepted. It can be defined as a psychological processRead MoreStudent s Achievement And Participation Rate868 Words   |  4 PagesMost of the refugee students are not able to get benefit fr om government once they have turned 18 years old. This is definitely an issue for them as they are not able to work to earn money. The school principle established a trust fund name â€Å"Friends of Zainab† (D Hoddinott Sydney Public Hearing April 4 2014). This fund provide support for young refugee students. However, this fund is not available for refugees in a community detention center or on bridging visas. Refugee students generally are disengageRead MoreThe Common Problems Faced By International Students Essay1388 Words   |  6 PagesThe most common problems faced by international students in UK Feeling Homesick You may feel homesick, as do many students, however for international students it is more difficult to deal with. Students from this country may be able to return home for a visit to help alleviate their homesickness. International students are not able to do this. This means that you may need more support than home students. You may need to talk to someone in confidence about how you are feeling. The counselling service

It Takes A Village, Educating Tomorrow s Leaders Today

Name: Richards, Blair K. Date 31 October 2015 Module 1 SLP It Takes a Village, Educating Tomorrow’s Leaders Today I. Introduction Introductory Paragraph A. In addition to the vital role that parents plays in their child’s education, additional family members and the community as a whole have a responsibility to ensure that each child is provided a high quality education. B. The first and most vital member of the education process is the parent. The second member that influences a child’s education is additional family members, from siblings all the way to grandparents. The third and final person/person(s) responsible for the education of our future leaders are the community member, from teachers, coaches, to volunteers. C. Raising and educating children is no longer just a parent’s job, but the collective process of all the members of community, it literally takes a village to raise a child. II. Body First Body Paragraph (1st supporting point) A. As the primary caregiver and professor from the days a child learns to speak and walk, parents play the most vital role in a child’s education. B. The interaction between parents and child from the earliest days help develop the bond of teacher and pupil. Before our child enters into elementary school and secondary education, the parent provides all of the educational needs, from counting, reading, writing, and saying the alphabet. Once the child enters into the schooling system, the responsibility ofShow MoreRelatedThe Great Northwoods Essay7709 Words   |  31 Pagesformation of the Nicolet National Forest. Specifically, I plan to go into a more detailed account of forest depletion and the tragedies that resulted from it. Finally, I shall move into the conservation movement. With the failure of agriculture to take a firm hold, the conservation movement led the government to purchase large tracts of land in an effort to save what little was left of the great forests of Wisconsin. Fires had become rampant within the region, lives were being lost, and the governmentRead MorePtv Internshipreport9500 Words   |  38 Pagesstrength courage to complete this project. I pay my gratitude to my kind teachers for their precious guidance lead me able to be at this stage. I dedicate this sincere effort to my respected teachers, friends loving parents for their today sacrifice for my better tomorrow CERTIFICATE Certified that Internship Report submitted by MR. MUHAMMAD ANWAR Student of MBA (Final) on Pakistan Television Corporation Islamabad partially fulfills the requirement for the award of degree of Master of Business AdministrationRead MoreProductivity and Quality Management9708 Words   |  39 PagesProductivity could be further shown as a conceptual model which takes the form of a productivity tree. The roots denote the inputs to the system, the trunk the conversion process the foliage the fruits the systems out put,1 Table 1.Productivity as a Conceptual Model 1.1.1.1 Why productivity Productivity is a must for all, this would apply to individual human beings, the organizations they work for, the industries , the nation the global village as a whole. The benefits they attain includes, hireRead MoreMarketing Management130471 Words   |  522 Pages Marketing management – an introduction Unit structure: 1. Introduction 2. Learning Objectives 3. Marketing Management 3.1. Evolution of marketing management 3.2. The Role of Marketing 3.3. Marketing concepts 3.4. The Marketing Mix (The 4 P s Of Marketing) 3.5. Corporate Social Responsibility (CSR) and Ethics in Marketing 4. Have you understood type questions 5. Summary 6. Exercises 7. References 1. INTRODUCTION: The apex body in United States of America for the Marketing functions, AmericanRead MoreInfluence of Pta on School Adminsitration11087 Words   |  45 PagesHowever, schools have been holding the community performance in the school with suspicion as observed by Musaazi (1984:242) that parents consider the job of teachers as merely instruction in the classroom not organizing productive activities in the village or doing other community development, type of activities. Teachers do sometimes reject the idea of having local villagers (parents) to participate in managing the schools. This kind of feeling among the teachers has therefore made parent s to regardRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 Pagesand permission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any form or by any means, electronic, mechanical, photocopying, recording, or likewise. To obtain permission(s) to use material from this work, please submit a written request to Pearson Education, Inc., Permissions Department, One Lake Street, Upper Saddle River, New Jersey 07458, or you may fax your request to 201-236-3290. Many of the designations by manufacturersRead MoreLibrary Management204752 Words   |  820 PagesCongress Subject Headings: Principles and Application, Fourth Edition Lois Mai Chan Developing Library and Information Center Collections, Fifth Edition G. Edward Evans and Margaret Zarnosky Saponaro Metadata and Its Impact on Libraries Sheila S. Intner, Susan S. Lazinge r, and Jean Weihs Organizing Audiovisual and Electronic Resources for Access: A Cataloging Guide, Second Edition Ingrid Hsieh-Yee Introduction to Cataloging and Classification, Tenth Edition Arlene G. Taylor LIbRaRy and InfoRMaTIonRead MoreManagement Course: Mba−10 General Management215330 Words   |  862 PagesFourth Edition I. Management 17 17 2. The Evolution of Management Thought Hughes−Ginnett−Curphy †¢ Leadership, Fifth Edition I. Leadership is a Process, Not a Position 51 51 70 1. Leadership is Everyone’s Business 2. Interaction between the Leader, the Followers the Situation Cohen †¢ Effective Behavior in Organizations, Seventh Edition 11. Leadership: Exerting Influence and Power 94 94 Text Palmer−Dunford−Akin †¢ Managing Organizational Change 2. Images of Managing Change 121 121Read MoreOne Significant Change That Has Occurred in the World Between 1900 and 2005. Explain the Impact This Change Has Made on Our Lives and Why It Is an Important Change.163893 Words   |  656 Pagesmore severe and widely distributed throughout societies across the globe than at any other time in human history. She traces the ways in which humanitarian impulses—which were often linked to pacifist movements and largely confined to visionary leaders, social thinkers, and small groups of activists in the 1890s—were institutionalized on a global basis by the establishment of the League of Nations and its subsidiary agencies in the aftermath of the catastrophic war that engulfed much of the worldRead MoreStrategic Marketing Management337596 Words   |  1351 Pagespivotal role in strategic marketing planning 10.6 Summary 11 The formulation of strategy – 3: strategies for leaders, followers, challengers and nichers 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 11.9 11.10 11.11 11.12 11.13 Learning objectives Introduction The influence of market position on strategy Strategies for market leaders Marketing strategy and military analogies: lessons for market leaders Strategies for market challengers Strategies for market followers Strategies for market nichers Military

Short Essay Questions on Six Literary Works - 1257 Words

PART ONE – SHORT ESSAYS Question 1 Janet Mock is a famous transsexual woman who experienced her rebirth of a woman. As she grows up, she faced many difficulties which made her to struggle a lot. Many students bullied her and even the teachers criticized her because she was acting like a girl, just because she was a boy. However, she did not give up and did not afraid to express herself as the way she is. She was able to stay strong after the turning point of her life, meeting her friend, Wendi. Janet’s relationship with Wendi changed Janet intensely and became very valuable as she was becoming sure of what she undoubtedly craves. Wendi, just like Janet, she was born as a boy, but she hoped for a change of her gender to a girl. When†¦show more content†¦When he was in the France, he fell in love with Giovanni and stayed in his room together. When David and Giovanni talked about sexuality, they referred to their own places. They used comparison between America and Europe, and talked about the difficulties they had to come through. However, David could not create his real sexual identity in the America, but also he couldn’t be sure of it even though he was in Europe. David tried not to love him since he thinks it is rightful him to fall in love with a woman, not a man. However, Giovanni did not afraid to present his affection towards David. Because Giovanni was from Italy, he thinks loving someone who has same sex as him is not a big deal. David masked his true identity by loving a woman, Hella. When she was away from France, she said yes to David’s proposal of marriage. Finally, when she came back, David went to her and decided to hide his emotion towards to Giovanni. Eventually, David left Giovanni to marry with Hella. Although he was far away from the America, he had to hide himself like he was at his hometown. Although David was looking for his sexual identity in a different place rather than in America, he couldn’t accept his realness and chose to hide and destroy his true identity. Question 3 Since the book, Beloved by Toni Morrison mostly concerned with dualities, there are many contradictions which described in theShow MoreRelatedSilvia Parra Dela Longa. Professor: Leslie Richardson.1404 Words   |  6 PagesSilvia Parra Dela Longa Professor: Leslie Richardson ENGL 2342 26 February 2017 The Style of Ernest Hemingway According to critic Robert McCrum, associate literary editor of The Observer, and writer of six novels (theguardian.com) The Sun also Rises ranks number 53 on the list of the 100 best novels of 20th century American Literature. Why does The Sun Also Rises is respected as landmark in the world of words? One of the reasons is about the writing style of Hemingway, which transformed the pathRead MoreThe Things I Know Nothing At All : A Little Thing From Experience1632 Words   |  7 PagesThe title of my project is called The Things I Know Nothing at All: A Little Thing from Experience. The genre is diverse and falls under the categories of prose poetry, micro fiction, or creative non-fiction. It is inspired by Anne Carson’s Short Talks where she analyzes different subjects that are interconnected on a grander scheme. I used Janet Burroway’s Imaginative Writing: the Elements of Craft to create my creative non-fiction piece and to develop its subjects. The goal of my proje ct is toRead MoreAspects of Postmodernism in Happy Endings and Videotape1523 Words   |  7 Pagescharacteristics of this relatively new current are well exposed in short stories such as Happy Endings by Margaret Atwood (Atwood) and Videotape by Don Delillo (Delillo). In this essay, we will first look at some basic elements of postmodernism and then we will closely examine the ways each of those two short stories exemplifies this type of fiction. Let us start with the examination of some features of postmodernism. To begin with, Bessner provides six characteristics of postmodern writings and he affirmsRead MorePractice Never Makes Perfect : Is It Perfect?1480 Words   |  6 Pagesinteraction with a live person. There was no school classroom, no video screen, just a chat box and a microphone. Ever since I could remember, I always detested speaking over the phone with people I never met. The instructor made us each read a question out loud or verbally explain an answer through the microphone. At first, I was extremely uncomfortable with the whole communication situation; however, the more I practiced, the more comfortable I felt using the microphone. That was until one sunnyRead MorePractice Never Makes Anyone Perfect1490 Words   |  6 Pageslack of interaction with a live person. No school classroom, no video screen, but just a chat box and a microphone. Ever since I could remember, I always detested speaking over the phone with people I never met. The instructor made us each read a question out loud or verbally explain an answer through the microphone. At first, I was extremely uncomfortable with the whole communication situation; however, the more I practiced, the more comfortable I felt using the microphone. That was until one sunnyRead MoreThe Raven And The Overwhelming Power And Sadness Of The Death Of A Loved One1165 Words   |  5 PagesCritical Analysis This critical analysis essay is about Poet Edgar Allen Poe’s poem â€Å"The Raven† and the overwhelming power and sadness of the death of a loved one. There is such sorrow and even anticipation that the poem invokes in the reader. The poem can be quite dreary and full of gloom, but the author also makes it sound eerie but somehow beautiful and lyrical especially when reciting it orally. Poe was a remarkable writer and known as being a bit peculiar in person and in his writings. PoeRead MoreAn Analysis Of Armand Aubigny s Desiree s Baby 1538 Words   |  7 Pagesthe responsibility of raising six children. She never remarried† (Koloski). Ten years after her husband’s death, Kate wrote a short story named â€Å"Desiree’s Baby.† A few years passed, and Chopin’s short story was finally published in Vogue among others. Its strong message about controversial issues such as racism and discrimination of females earned her acclamatory fame and acknowledgment. By the time of her death, Kate Chopin had already written about a hundred short stories and two novels. 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Internal Control of the System for B ltd Company- myassignmenthelp

Question: Discuss about theAccounting For Business Combinations for Financial Reporting. Answer: Introduction Non-current assets are goods which cannot be readily converted into unrestricted cash within a period one financial year (Deegan, 2013). These assets are further classified as tangible and intangible goods. Intangible assets are held in a balance sheet for a period exceeding one financial year, they are non-physical, e.g. copy rights, and patent. Tangible goods are physical and may include land, buildings, and equipment (Malmi, and Brown, 2008). The acquisition and disposal of these tangible non-current assets is a challenge to most companies, this requires the laying down of appropriate foundations, term and conditions for the acquisition and disposal. Every company places all its effects in these to ensure accountability and transparency in its management. B ltd Company has laid down the procedures for the acquisition and disposal of its tangible non-current assets In this paper will discuss the strengths of the internal control for the acquisition and disposal of tangible non-current assets as laid by B ltd and propose the procedure for testing the internal control of its system. Strengths of internal control of the acquisition and disposal of tangible non-current assets of B Ltd. A purchase requisition form is completed and approved by the departmental manager for acquisition of new assets. This enables the department to be accountable on what is needed by the company for the efficiency of its operations. Some companies have their decision making, on what is needed and irrelevant in the company placed at the top of its management. B Ltd. Will not purchase any irrelevant tangible assets since it has full involvement of its employees, it is at the department level where the decision for the approval of the acquisition of any commodity is made. The acquisition is approved in the consideration of the needs of the company at the specific time. This helps in streamlining the process of new purchasing asset by the company. The purchase requisition form is checked by the purchasing officer for approval. Then, the Purchasing officer completes the purchase order. The purchase order indicates the agreed price, type and the quality of the commodity ordered. The consistency of information is maintained, the information contained in the purchase requisition form is approved. The quality of commodity and type needed is clarified that binds both the supplier and the company making the order. It helps for clarification of the information and correction of any errors that may have been unnoticed by the departmental manager when completing the assets requisition form. The financial accountant approves acquisition of new assets over $5000. The board of Directors approves purchase of new assets over $10000. This helps in monitoring huge expenditures by the company. B Ltd cannot spend large amounts of finances without the approval of the top management. It keeps the company away from the risk of overspending and running short of its finances due to large expenditures without approval from the board of directors. The board of directors has the authority to approve or deny the request for expenditure. They are holds the accountability of large expenditures by the company. The financial accountant also holds the responsively of expenditures below 5000 US dollars. In case of any misuse of the companys finances someone is held accountable since all the decisions made are certified by a certain individual. A copy of the purchase order is sent to the supplier and to the head office. The buyer indicates the quality, type and the price of each commodity ordered. The purchase order controls the purchase of commodities from the external suppliers hence avoiding confusions within the company. Once this document has been agreed by the supplier, it becomes a binding contract between the supplier and the buyer. Important information is communicated to the supplier, it also facilitate for ease in the tracking of any outstanding order by both parties (Zhihua, 2007). Once the quality, quantity and price has been communicated to the supplier, and a copy of the purchase order has been received by the supplier, it is the responsibility of the supplying company to ensure that it meets the standards specified in the purchase order (Romney, and Steinbart, 2012). The receiving clerk checks that the details of the asset purchased agree with those on the receiving report and the purchase order. The receiving clerk issues barcode numbers to the asset acquired. The barcode is attached to the asset and recorded on the receiving report and the supplier invoice. The receiving clerk has the responsibility to confirm the details in the order and identify any error that may have been unnoticed when writing the order. Issuing of number barcodes to the assets acquired helps in saving the time for tracking of the asset by providing more accurate efficient way to locate the assets (Dorf, and Bishop, 2011). The departmental manager keys in the details of the assets acquired into the asset register using a copy of the purchase order, the requisition form, and the barcode. Since the department manager filled the purchase requisition form, he uses the previous information to note any changes. The assets register filled helps in identifying all the fixed assets of the company by identifying the date of acquisitions, price, and where the asset is located. Once the asset is entered in the asset register of the company, the company bares the responsibility of maintaining and managing the asset. Entering the asset in the assets register means that the asset must be valued within the systems of the business (Hargie, and Tourish, 2009). An asset disposal form is completed by the departmental manager and a copy is sent to the financial accountant for approval. A copy of the approved asset disposal form is filed at head office and sent to the departmental manager for updating the asset register. The assets disposal form ensures that the asset to be disposed is handled correctly to facilitate transparency and accountability in the company. The decision to dispose the commodity is recorded in the disposal form and all the reason for the disposal is documented. This helps in preventing the disposal of assets in use by the company by irresponsible managers, and also guides the company in doing away with the assets that are not being used by the company (Furnham, and Gunter, 2015). The sending of the copy of assets disposal form to the financial manager for approval before a commodity is disposed is required for the auditing purpose. Once a commodity is disposed the assets register should be updated. This helps in the prep aration of the financial statement. The asset register is reconciled to the general ledger by the departmental manager monthly. The reconciliation of the register to the general ledger helps in the preparation of the financial statement because it contains complete financial transactions records related to the company assets and other important information. It has to be done regularly to ensure that the companys records are updated and prevent the back loading of unrecorded information. This make the work of preparing the financial stamen easier since all the information required is recorded (Porter, 2008). Depreciation is calculated monthly by the rate input by the departmental manager. Depreciation is the reduction of the recorded value of the fixed assets that helps to guide the company in deciding when the disposal or replacement of an asset is required (Buckley, and Caple, 2009). Depreciation calculation will help the B Ltd in accountability. Recommended procedures for testing the internal control of the system Internal control can be tested by the following seven step procedure. Separation of duties This is the breaking down of responsibilities for auditing, depositing, bookkeeping and reporting and assigning it to different personals. Access control The use of electronic access logs and passwords for the system to keep unauthorized persons out of the system Physical audit This is verification of the existence of an asset. It is done by hand count and can reveal hidden disparities in the system. Documentation This is normalizing documents used in accounting purposes. Trial balanced This is the use of a double entry account to ensure that the books of account are always balanced. Reconciliation It helps in ensuring that the balances held by other entities like bank is similar to the one in the accounting system. Approval authority This is giving responsibilities to authorize certain transactions to specific managers. Conclusion B Ltd has a well-structured system for the acquisition and disposal of tangible non-current assets. The system ensures that all the decisions made in the organization are based on sound consideration aimed to better the company. Accountability and transparency is also promoted by the system. Transactions involving large amount of money has to be approved by the board of management. There is no asset that can be disposed without a valid reason and consent of responsible personnel. The internal control of a system can be tested by the seven step procedure above. This ensures that the organization operations run effectively and efficiently. References Buckley, R. and Caple, J., 2009. The theory and practice of training. Kogan Page Publishers. Deegan, C., 2013. Financial accounting theory. McGraw-Hill Education Australia. Dorf, R.C. and Bishop, R.H., 2011. Modern control systems. Pearson. Furnham, A. and Gunter, B., 2015. Corporate Assessment (Routledge Revivals): Auditing a Company's Personality. Routledge. Hargie, O. and Tourish, D. eds., 2009. Auditing organizational communication: A handbook of research, theory and practice. Routledge. Malmi, T. and Brown, D.A., 2008. Management control systems as a packageOpportunities, challenges and research directions. Management accounting research, 19(4), pp.287-300. Porter, M.E., 2008. Competitive advantage: Creating and sustaining superior performance. Simon and Schuster. Romney, M.B. and Steinbart, P.J., 2012. Accounting information systems. Boston: Pearson. Zhihua, X., 2007. Internal Control, Corporation Governance and Risk Management: Relationship and Integration [J]. Accounting Research, 10(007).

Iliad-Odyssey Paper Essays - Trojans, Iliad, Epic Cycle,

Iliad-Odyssey Paper Hate to Love ?I lie upon my bed with my afflicted heart, besieged by tears so stubborn and so sharp that, even as I mourn, tear me apart? (Odyssey 19.610-13). The preceding quote made by the heartbroken and devoted Penelope in Homer's the Odyssey shows an intensity of feeling that is lacking within his earlier work, the Iliad. It is amid the latter epic that the female roles are able to step into the limelight and express the befitting emotion that give the Odyssey a philanthropic feel. Therefore it is the female characters within the Odyssey that incorporate attention to compassion because they demonstrate greater altruistic expression than men especially here when compared with the Iliad. In the Iliad the dominant role is played by men hence women had to wait backstage to prove their own complexity of character. The highly regarded ancient Greek society was overseen by the males, that is, the women weren't involved unless they had permission by the men. Women were valued -- the Iliad opens with the Achaian army's capturing of two beautiful enemy maidens, Chryseis and Briseis, who are then awarded as prizes to Agamemnon -- but, in comparison to men, their concerns weren't as proclaimed in early epic poetry. In the Iliad, for example, Hektor orders Andromache back into the house during the ensuing Trojan War: Go home, attend to your own handiwork at the loom and spindle, and command the maids to busy themselves, too. As for the war, that is for the men, all who were born at Ilion, to put their minds on -- most of all for me (Iliad 6.436- 40). Hektor also desires his own baby son to be a great warrior rather than being active in domestic affairs as he prays: O Zeus and all immortals, may this child, my son, become like me a prince among the Trojans. Let him be strong and brave and rule in power at Ilion; then someday men will say ?this fellow is far better than his father!' seeing him home from war, and in his arms the bloodstained gear of some tall warrior slain -- making his mother proud (Iliad 6.419-27). (Ironically, just before Hektor made this plea to the gods his baby ?squirmed round...and began to wail, terrified by his father's great war helm? and thereafter was comforted by his mother's ?fragrant breast? as she ?held and cherished? her small son.) Later when Hektor becomes frightened of the realness of encountering Achilles he says, ?Aye, then and there he'll kill me, unprotected as I am, my gear laid by, defenseless as a woman? (Iliad 22.149-51). However, it's in the Odyssey that a man puts his trust -- his own life's safety -- in a woman to direct and protect him on his arduous journey. The men of the Iliad are incredibly jealous creatures whereas in the Odyssey they show sensitivity that rivals that of the women who have enhanced their shrewdness. Achilles gets angry because Agamemnon acquires the ?best? war prizes without fairly earning them: You [Agamemnon] thick-skinned, shameless, greedy fool!.. . . Never have I had a plunder like your own from any Trojan stronghold battered down by the Akhaians. I have seen more action hand to hand in those assaults than you have, but when the time for sharing comes, the greater share is always yours. Worn out with battle I carry off some trifle to my ships (Iliad 1.175-196). -#- Achilles later sits and weeps childishly to his mother, Thetis, over his prize being rewarded to his adversary. Thetis actually feels responsible for her son's misery as she declares, ?Oh early death! Oh broken heart! No destiny so cruel! And I bore you to this evil!? (Iliad 1.481-2). The mother never scolds her son. In contrast, Odysseus becomes more empathetic throughout the Odyssey because Athena brings out a new humaneness within the hero. Odysseus refrains from gloating after he kills the suitors that have overtaken his palace and scolds his maid for rejoicing: ?Old woman, check yourself; you must restrain your joy -- don't shout aloud. It is profane to let your voice exult when men are slain? (Odyssey 22.480-83). His selfless attitude gives the poem passion, warmth, and balance all of which set it apart from the tone of harshness within the Iliad. There's little opposition from the female characters while the revengeful men of the Iliad are constantly fighting one another whereas in the Odyssey battle is less of

Crafting Strategy Essays

Crafting Strategy Essays Crafting Strategy Paper Crafting Strategy Paper Henry Mintzberg’s Crafting Strategies is based on conclusions from decades of research that tracked 11 organizations through important moves they made in the observed period. . Patterns were marked and lumped as strategies, graphically showing distinct periods of stability, flux, or global change. (Mintzberg:75) His thesis: strategizing is more of crafting a strategy a potter shaping clay aware of her past experience and her future prospects as she performs her craft.. In contrast, the popular notion of bosses rationally and precisely plotting strategy in corporate meetings is an inaccurate depiction of strategizing and therefore misguides those who adhere to this notion uncritically. The article only seems to tilt towards an emergent approach to strategy. The author argues that a key to managing strategy is the ability to detect emerging patterns and to help them take shape. A manager’s job is not merely to see ahead but to detect patterns and get involved when the time is ripe. (Mintzberg:74,75). But Mintzberg also clarifies that all strategy making â€Å"walks on two feet: deliberate and emergent. † Purely deliberate precludes learning, and purely emergent has no control. Neither approach makes sense, which explains why strategy means emergent and deliberate behavior. (69) Mintzberg’s theory therefore also aptly captures the ideal mix of the four archetypes of Richard Whittington’s classical, evolutionary, systemic, and processual schools of strategy. These archetypes are in fact meant as conceptual reference points, set up in descriptive archetypal quadrants that are not necessarily exclusive of each other. In his interpretive article, William Sheridan aptly applied Whittington’s conceptual framework. His summary of Whittington is this: that strategic thinking requires conceptual space in which there is room for different policies, tactics, and intelligence gathering. Within each strategic space, the four archetypal quadrants each stand up for different assumptions, goals, methods, and perspectives. Sheridan translated the four quadrants into their operational core as behavioral, institutional, societal, and cognitive. He said strategic thinking now means anticipating and preparing for implications and consequences of present actions. Whether acting alone (classical), on behalf of another(evolutionary), or as adviser (processual), or as societal leader (systemic) , strategic thinking (considers ) the interests of all stakeholders to protect systemic integrity. (Sheridan: full article). Sheridan then intertwined Whittington and Mintzberg: The craft of strategy consists in identifying the mix of appropriate policies, deploying them as needed, and staying alert to the prospect that changing circumstances will require changing the mixture. Citing Mintzberg, within the context of Whittingtons four schools of strategy, Sheridan summed up that strategy is not predominantly rational modeling nor formal planning, but rather an informed overview, of which the key factor is the breadth of strategic thinking also labeled as wisdom in Crafting Strategy. (Mintszberg: 69 ) Mintzberg’s theory captured the four archetypes of Richard Whittington’s classical, evolutionary, systemic, and processual schools of strategy archetypes that characterized the potter as a craftman strategist. Theoretical Underpinnings, Assumptions on strategy, business environment or organizations of the essay : Is the author’s worldview rational or based on logic/chaos/uncertainty? Are the assumptions realistic? In the book Critical Approaches to Strategic Management by David L. Levy, Mats Alvesson and Hugh Willmott the authors concede that much current thinking on strategic management is anchored on the work of Michael Porter and Henry Mintzberg. Mintzberg and colleagues (1998) with their ten schools and five definitions of strategy. My own random survey of literature on strategic management shows the complexity of the task of selecting strategies, and the overload of very involved prescriptions and descriptions of strategy. Levy and group have panned against Mintzbergs approach for its skeptical look on established classical and rational perspectives. They note that his views miss broader issues of domination and fail to scrutinize managerial assumptions. For example, Mintzbergs view on power tends to look at this issue narrowly within an intra-organizational perspective that eschews broader social and political issues, according to these same authors. Though Mintzberg shares the basic comprehensive perspective of Whittington, I believe his school of thinking shows a palpable emphasis on the micro side of strategic management. Under his method, broader social issues affecting management concerns ( for example , current issues as the Wall Street crash and our problems in Iraq, etc) would have to be relatively relegated to the rear ground, and this may not serve the end of strategic management. Sheridan is right that in terms of social insights, critical theorists of strategic management have the edge. In the present essay, Mintzberg cited the example of GM as a large and complicated organization, describing the complexity and confusion that gets tucked under the veneer of strategic order meetings, debates, dead ends, folding and unfolding of ideas as the company pursues its strategies. (68) From its lens, Crafting Strategy sees the reality hidden in the veneer of strategic order. As a craft theorist, one would see alternately a balance of chaos or order. The craft theorist would therefore not just think of new clever strategies, but allow them to develop gradually. His strength would be in the intuitive balance, his espousal of both learning and controls, his responsiveness to the material at hand. (69) In this context the theory is receptive to application, creativity, and intervention. Crafting Strategy: Main strengths and weaknesses –Persuasive Power and Basis of Persuasion Within the framework of its own assumptions and findings, Henry Mintzberg’s â€Å"Crafting Strategy† has a persuasive expressive content. It however presents a doubtful diminution of previous schools of strategic management , arguably presenting itself as a comprehensive modifying school of thought. (Sheridan: c. 2003). On the other hand it has yet to offer operational tools for managers confronted with, for example, labor unrest or racial inequity. Of course its adherents may argue that managers schooled in its perspective would have the sensitivity and other skills of the craft, but as negated by Levi et al, its relative de-emphasis on broader social issues may limit management leaders from the optimal application of established strategic tools. If anything can be said on Crafting Strategy , it is that its arguments are always nuanced. For example, it upheld both the grass roots approach to strategic management, and its opposite, the hot house strategy, estimating Reality falls somewhere between the two. (68) There is however no evidence presented that traditional tools espoused by other schools of thought have necessarily become obsolete, even granting that those findings on the research basis of its thesis have been validated. Also, the example of 11 observed firms may be a statistically insignificant in a universe of millions of counterparts in other countries. Finally I find the potter inadequate as a metaphorical parallel of corporate reality. The metaphor fails to capture the sophistication of managing complex emotions, social distinctions, biases, intrigues, competition in the marketplace, corporate politics, etc†¦that are the problems of strategic management.

Week 6 _Assignment Essay Example | Topics and Well Written Essays - 750 words

Week 6 _Assignment - Essay Example It provides authentication as well as integrity of data and information of the user (Interpeak, 2005). IP Spoofing- An intruder connects to host server by duplicating his/her IP address when address-based authentication is been used. The IPSec protocol uses cryptographic authentication rather than address-based authentication for protecting from IP spoofing attack (Oppliger, 1998). Session Hacking- An intruder can connect to a server which is authenticated. At that point of time, IPSec helps to protect the connection as the intruder does not know the session key necessary for encrypting the data stream (Oppliger, 1998). Denial-of-Service- An intruder sends TCP messages to flood buffer space of targeted system but if there is IPSec protocol it will provide a denial-of-service attack and will reveal intruder’s identity if he/she is using original IP address (Oppliger, 1998). Application layer manages views of the user over the network. It defines about the processing of the application on different systems end communicate over the network. All the processes which are running in various systems or else end-users communicate with the help of application layer protocol (Rouda, 2006). XML stands for Extensible Markup Language, which is used to encode document in a format which is understandable by both human beings and machine. It facilitates to develop a common format of information in a flexible manner. Yes, it is possible to design a universal security solution at one layer. Generally, security suites work on one layer without collaborating with other protocols. A security system can be build with single layer of the Open Systems Interconnection (OSI) model. The OSI model is really a theoretical device used to help explain how the network and internet functions. When a Web communications is secured using Secure Sockets Layer (SSL) which is used for securing message transmission

Economic Recession of United Kingdom Essay Example | Topics and Well Written Essays - 1000 words

Economic Recession of United Kingdom - Essay Example An annual decline in terms of quarterly gross domestic product (GDP) in real terms for a minimum of two consecutive quarters is known as technical recession. Nevertheless, proponents argue that this classification ignores the variables of unemployment and consumer loyalty. A broader definition tends to suggest a recession as period of falling economic output and employment. In addition, another definition also exists based on the diagrammatic model of life stages of an economy. It illustrates that recession begins when economic activity is at apex and starts decelerating and ends when economic activity hits bottom and then starts accelerating. Recession and Depression are often confused together. The prime distinguishing factor relates to quantities, Recession beyond a particular rate is termed as depression. A primary illustration was The Great Depression in America during 1929-1933 when the gross domestic product crashed down by nearly 33 percent. Recession The early 1980s witnessed the challenging economic worldwide recession, which influenced majority of the developed nations during the period of 1970s and 1980s. The repercussions of recession were evident in America and Japan quite early; nonetheless, high unemployment adversely influenced other Organisation for Economic Co-Operation and Development (OECD) countries almost until 1985 (Moy). The long-term consequences resulted in the debt crisis across America and Latin, the savings and loans catastrophe that hit America; therefore, more neoliberal economic approach was adopted during the 1980s and 1990s.

Compare the way a news story is presented in three different newspaper extracts Essay Example for Free

Compare the way a news story is presented in three different newspaper extracts Essay In this essay I will compare the way a news story is presented in three different newspaper extracts. Extract A is from The Times on Tuesday 4th September, extract B is also from The Times on Tuesday 4th September extract b is an editorial, extract c is from The Guardian G-2 on Friday 7th September extract c is a front page graphic. All three extracts cover the event that happened on Monday 3rd September between the Catholics and the Protestants. The incidents occurred when Catholics school children from Holy Cross Primary school began there new school year. The children had to walk in between barriers of armoured police, just to get to school. The incident started when republicans was accused of knocking over two men on ladders who were putting loyalists flags on lampposts out side Holy Cross Primary School before the marching season in June. In all three extracts there is a powerful opening statement to catch the readers attention, extract A uses a pun the young girls of the Holy Cross Primary School in Belfast began their new school year yesterday with a horrifying lesson in sectarian hatred. This is trying to say that in schools children are learning about hatred instead of being taught other lessons such as getting along with everyone regardless of whether they are Protestant or Catholic. Extract B also uses a powerful opening statement Northern Ireland has yet again shown its Gorgon-face of bigotry. This states that once again Northern Ireland has shown its monstrous side, whereas extract C states Why it takes the image of a child to wake the world this makes the reader to feel sorry for the children and is an rhetorical question. Extract A has a big, bold headline it states Children walk a gauntlet of Belfast hatred which makes the reader to want to read on. Extract B states Children in the middle this is also trying to get the attention of the reader, whereas extract C doesnt have a headline because it is a front-page graphic. Extract A uses a certain amount of emotive language to make the audience feel certain emotions. Extract A states screamed at not shouted at but screamed at, spat at use of abuse on children, sobbing uncontrollably this states that the children werent crying they were uncontrollably sobbing due to the riots. The emotive language in extract A has a certain effect on the audience, it makes the reader feel sympathetic towards the children. Extract B also uses a certain amount of emotive language using words such as Gorgon-face of bigotry and hideous spectacle. These words are usually associated with beasts, therefore this statement is trying to show that what is happening, should be considered as monstrous and that the victims of this monstrosity are innocent children. Surrounded and overwhelming are adjectives meaning that there is no way out for the victims, showing that the whole situation cannot be resolved. Extract B is an editorial and is the editors point of view not the facts. Extract C doesnt use a lot of emotive language mainly because it is a front-page graphic from a supplement.

Replication Of Human Pheromones :: Biology Essays Research Papers

Sexual Or Sexist? Replication Of Human Pheromones From the elixer in Love Potion Number Nine to the Orgasmatron in Orgazmo, the media reflect a popular fascination with the idea of an object that can control other people's sexual desires and behaviors. On a similar but dorkier note, I have occasionally heard at Haverford someone attribute a sexual "lucky streak" to the influence of pheromones. In our well-educated but socially awkward mind frame, we have hit on a more promising possibility than magic potions or radar guns. From the Greek for "excitement carrier", pheromones carry chemical messages between members of the same species (2). Present in many animals and often responsible for aspects of mating behavior, the idea of pheromones in humans has in recent years been a subject of interest. The idea of pheromone perception as a "sixth sense" is intriguing, as it means our behavior is influenced by input from outside stimuli that we cannot consciously perceive. Evidence points to the output by and influence on humans of natural ph eromones, and these pheromones are under attempt at imitation by commercial products. What are the possible ramifications of such developments? Experimental evidence also shows differences in the way men and women respond to pheromones, and the possible implications of these differences on gender roles is the aspect of human pheromone research that interests me most. These chemical signals are detected in the vomeronasal organ, or VNO, which is present in the noses of most species of vertebrates. In other mammals, the VNO is located in a longitudinal bulge at the base of either side of the nasal septum (4). Humans lack this bulge marking the position of the VNO, and although there are nerve bundles running from the human VNO to the brain, it is still unclear whether they contain actual sensory neurons or just autonomic nerves. Unlike that in animals, the human VNO does not have an obvious sensory epithelium; however, it contains cells that are considered to be bipolar receptor neurons. The human VNO is thought to be stimulated by airborne chemicals, as opposed to stimuli dissolved in mucus (3). Although most exploration of the possibilities of human pheromone perception has happened recently, scientists have known about the human VNO since 1703, when Dutch surgeon Roysch discovered it in the nose (2). Since then the VNO has been commonly thought to be present only in fetuses, disappearing over the course of prenatal development.

La Misma Luna Review

La Misma Luna review The first theme I think of when it comes to the movie La Misma Luna is big things come in small packages. Carlos is nine years old, yet he is determined to cross the Mexico border to find his mother. Most nine year olds are focusing on what picture they want to color next, not Carlos. I felt really touched by what Carlos is trying to accomplish. Carlos comes across many obstacles on his journey to his mother. He eventually comes across Enrique, who turns into his travel buddy, and saves him numerous times. I really admire Enrique for all he did for Carlos.Although he wanted to leave Carlos many times, Enrique stayed by his side, keeping him from danger. I feel like I am most like Enrique for the fact of how he helps Carlos. I am always helping people, whether I get along with them, or even like them, I’m always there to help. I also relate to Enrique because of his determination. He is just like Carlos, determined to find his mother (Carlos’. ) Toge ther they go through many struggles, sleeping on park benches, finding cheap easy jobs, barley making enough money to eat and sleep. But they will do whatever it takes to find her.I am determined like them when it comes to basketball. I am also willing to work as hard as I have to win, start, score, and play as much as I can. Enrique saved Carlos from danger numerous times. This brings me to my next theme, that you can do anything you put your mind to. When Carlos was working in the tomato factory, he almost got caught; and I was very frightened at this point. He didn’t think for a second he was going to get caught. He hid himself in crates of tomatoes and waited. All during the movie, whatever he puts his mind to, he does.The most obvious goal Carlos accomplished was finding his mother. He walked the streets of Los Angeles looking for the special corner, with the pizzeria, Laundromat, party store, and murals on sides of buildings. That is true determination. But this shows t rue courage of Enrique. He could have easily left Carlos behind, for him to get caught. But he didn’t and that is something to look up to. True friendship and courage is what makes this movie so special. Without Enrique staying beside Carlos, no matter how annoying he got the movie wouldn’t have been the same.Without Enrique, Carlos would probably have gotten kidnapped, or found by the police and sent back to Mexico. It’s true friendship for Enrique to throw his coffee at the police when they had a hold of Carlos. Carlos was then able to escape, but it was not the same for Enrique, and I have a feeling he knew that when he threw the cup. The significance of the title is that no matter the distance between Carlos and his mother, they were always close to each other. They are under the same moon no matter what.

Categorical Imperative - 2266 Words

categorical imperative n. In the ethical system of Immanuel Kant, an unconditional moral law that applies to all rational beings and is independent of any personal motive or desire QUICK FACTS * NAME: Immanuel Kant * OCCUPATION: Philosopher * BIRTH DATE: April 22, 1724 * DEATH DATE: February 12, 1804 * PLACE OF BIRTH: Kaliningrad (now Konigsburg), Russia * PLACE OF DEATH: Kaliningrad (now Konigsburg), Russia Profile Immanuel Kant was born on April 22, 1724, in Kaliningrad (now Konigsburg), Russia. While tutoring, he published science papers, including General Natural History and Theory of the Heavens in 1755. He spent the next 15 years as a metaphysics lecturer. In 1781, he published the first part of†¦show more content†¦In the Groundwork for the Metaphysics of Morals, once Kant has derived his categorical imperative he applies it to a number of examples. The second example and probably the most analysed is that of an unfaithful promise. Kant applies his imperative to a person who is short of money who intends to ask for a loan, promising to repay it, but with no intention of doing so. When Kant applies the categorical imperative to this situation he discovers that it leads to a contradiction, for if breaking promises were to become universal then no person would ever agree to a promise and promises would disappear. Kant connects rationality with morality, and sees contradictory behavi our as immoral. Some critics have argued that Kant never asserts the connection between rationality and morality, but most dismiss this and point out that Kant clearly explains how morality must be based upon reason and not upon desires. Rejection of Aristotle Especially important to Kant were the worksShow MoreRelatedcategorical imperative2232 Words   |  9 Pagesï » ¿Explain with examples, Kant s theory of the Categorical Imperative Kant believed that there is an objective moral law this meant, he did not depend on a point of view. 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One of the most influential deontological philosophers in history is Immanuel Kant who developed the idea of the Categorical Imperative. Kant believed that the only thing of intrinsic moral worth is a good will. Kant says in his work Morality and Rationality â€Å"The good will is not good because of what it affects or accomplishes or because of it’s adequacyRead MoreCategorical Vs. Categorical Imperative1929 Words   |  8 Pages An imperative can be described as either a requirement or an order such as an assistant manager being told to take inventory or being told by a personal trainer to do fifty squats. All imperatives, no matter what it is, can either be hypothetical or categorical. A hypothetical imperative would be defining an action to be good if there is â€Å"a means to do something else†. (Landau-Kant 93) An example of a hypothetical imperative would be to do an action in order to achieve a specific result. On the

Essay On The Original Abbey - 1505 Words

The original abbey was a Chapter House, built in 1160. It was used by the canons as the place for business meetings and had stalls situated around the walls for seating; the canons would have met here in the morning, held services, be assigned tasks and be disciplined. Architecturally, it is Norman with the curved arches and is one of the only surviving original parts of the Abbey that would have included different rooms for the canons which governed their daily lives and a church. However, the eastern wall was rebuilt after the 1831 Bristol Riots, hence the modern windows. These windows now list the Abbots of the original monastery and the Deans of the Cathedral. The Chapter house is now a much more communal area and is used for community†¦show more content†¦Additionally, the chapel was not originally attached to the main building however it was eventually joined to the North Transept. The chapel contains lots of artwork, including the medieval tomb of Lady Margret Mortime r and Lord Maurice Berkeley, as well as the iconography of Saint Augustine of Hippo and local Saint Jordan. It is clear from the brickwork that the Elder Lady Chapel has been developed over time, the ceiling is noticeably different to the walls, which also differ from each other. Built in 1298 by Abbot Knowle was The East End ( Eastern Lady Chapel). It continues with the gothic architecture, very popular at the time and first introduced to the Abbey by Abbot David. The East End has large pointed windows which let light fill the space and is Englands largest hall church - this means all the ceilings are the same height, usually only the aisle ceilings are the same. There are also painted ceilings and painted designs, suggesting the Abbey was wealthy at the time. At the heart of the east end is the Choir, it is one of the most important and original works of the medieval era in Europe. It is at the center of the cathedral and was rebuilt by Abbot Knowle in the 14th Century, the choir stalls were later added by Abbot Elyot in the 16th Century. The current stalls date back to the 19th century but incorporate some of the 16th Century carvings, including the original misericords. these are located under the choir seats and were originallyShow MoreRelatedThe Differences Of John Keats And William Wordsworth1169 Words   |  5 Pagesâ€Å"Lines Composed a Few Miles above Tintern Abbey†, he shows this substitution through conceiving beauty and truth regardless of existence. Similarly, Keats, whom also is an expressivist, proves to be so by also showing beauty and truth in his poem, â€Å"Ode on a Grecian Urn† while creating infinity among the substituted presence. Before the rise of Romantics, there was order. It was believed that the entire universe had a fixed order. As Pope said in his poem â€Å"Essay on Criticism† he called it the â€Å"Vast ChainRead MoreThe Role and Significance of the Monastic Life in Medieval Christianity1654 Words   |  7 PagesThe Role and Significance of the Monastic Life in Medieval Christianity What is monasticism? The central and original role of the monastic life can be drawn from the meanings of the words monk and hermit. the word monk comes from the Greek word monaches which means solitary and hermit from heremites a desert dweller. The early monks and nuns were just that: men and women who fled the worldliness of urban life and the ethos of a church that was at the timeRead MoreIn Westminster Abbey Analysis1710 Words   |  7 PagesEssay: â€Å"In Westminster Abbey† â€Å"In Westminster Abbey† by John Betjeman is a poem that tells the story of a woman in a famous church in London and her prayer to the Lord. Each stanza in the poem contains something that the speaker wants from the Lord. And as one reads through the poem, a more keen understanding of the woman praying is formed, and it is likely drastically different from the original perception gained in the first two stanzas. In â€Å"In Westminster Abbey,† John Betjeman uses the speaker’sRead MoreAnswers to Some Critical Questions1718 Words   |  7 Pagesyour mind. (Browne 171). In American Earth, the Abbey notes that ¦. the absence of motorized tourists, who stay away by the millions. And they stay away because of the unpaved entrance road, the unflushable toilets in the campgrounds, and the fact that most of them have never even heard of Archest National Monument (416). This is clear omission and skewing of the data simply because there is no data to back this up, this is supposition, and Abbey does not include the reasons why tourists do visitRead More Millennial Themes in The Prelude and Mont Blanc Essay1534 Words   |  7 PagesThe types and symbols of eternity, Of first, and last, and midst, and without end. (VI. 566-572) The unity of God, man, and nature is of course a common theme in Wordsworths poetry, having been given equally memorable treatments in Tintern Abbey and elsewhere, but it was the seemingly paradoxical sentiment of this passage from The Prelude that made such a strong impression on me. As John Beer points out in his article Romantic Apocalypses, Although traditionally the apocalypse and the millenniumRead MoreEssay about Biography f Rene Descartes864 Words   |  4 Pageslicensed degree in Law. In 1618, Descartes spent some time in the military where he was placed in a defense force of Maurice of Nassau, Dutch Republic. In 1622, Descartes came back to France. It was during this stay in Paris where he wrote his first essay called â€Å"Regulae ad Directionem Ingenii† also known as Rules For The Direction Of The Mind. In 1628, Rene moved to the Dutch Republic where he lived for over 20 years. During this time period, he learned more about mathematics, utilizing his spareRead MoreJoseph Franz Haydn Essays818 Words   |  4 PagesCathedral in Vienna, where he made an early living. He worked as a freelance musician, playing the violin and the keyboard instruments, accompanying for singing lessons given by the composer Porpora, who helped and encouraged him ( Boynick, 1). In this essay, I will discuss a brief overview of Joseph Haydns life. I will also talk about some of the pieces he has composed and how they changed music forever. In 1759 he was appointed music director to Count Morzin; but he soon moved, into service asRead MoreMacbeth, By William Shakespeare1220 Words   |  5 Pagesdirecting the film Macbeth, (Macbeth) and the essay will examine many aspects of the play including the main characters, personalities, themes as well as the important incidents in the film and the historical background. I have chosen Lady Macbeth as the main character for discussion. The 2010 film, saw Macbeth as Stalin and the weird sisters or witches were portrayed as nurses and then cooks. It was filmed in an abbey which retained some of the original scenes of Shakespeare’s play. The 2010 filmRead MoreThe Challenges Of Seamus Heaney1406 Words   |  6 PagesThis essay will analyse the challenges Seamus Heaney faced during the process of translation and writing, including his own conscious effort to make the play suitable for a modern audience. It will demonstrate how Heaney’s use of language and poetry aided in presenting modern ideas through the timbre of Irish/English diction and idiom in an attempt to make the play more ‘speakable’. Identifying features of Greek theatrical conventions and how Heaney used these to shape his play. 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Red Bull Marketing Plan - 1809 Words

Table of Content Introduction 2 Executive Summary 2 Current Marketing Situation 2 Market Description 2 Benefits and Product features 2 Product Review 2 Competitive Review 3 Distribution Review 3 SWOT Analysis 3 Strengths 3 Weaknesses 3 Opportunities 3 Threats 3 Objective and Issues 4 Objectives 4 Issues 4 Marketing Strategy 4 Positioning 4 Product Strategy 4 Pricing Strategy 5 Distribution Strategy 5 Marketing Communication Strategy 5 Marketing Research 5 Marketing Organization 5 Action†¦show more content†¦SWOT ANALYSIS Strengths The strong marketing strategy, which is the â€Å"buzz-marketing† strategy, which we have, is one of its main strengths because Red Bull is becoming a wide known brand all over the world. Weaknesses Red Bull is an undifferentiated product from competition. A lot of energy drinks are similar to Red Bull and this may affect us. Also, a lot of other energy drinks prices are lower than Red Bull which puts Red Bull a step behind some other energy drinks. Opportunities Red Bull has a large market share in the energy drink market and it is one of the most popular energy drinks in the world, this may help us to increase the demand for the product and maybe develop a new product within the same brand. Threats The energy drink market is a growing market and a lot of companies are entering it as they have found it to be attractive and profitable. Some of these companies are growing rapidly and they present a threat to Red Bull. One of those companies that are getting stronger by time is Power Horse. OBJECTIVE AND ISSUES Objectives: We set some hard and ambitious but achievable objectives. Our objective is to increase our market share, which is about 60% into 75% in two years and to maximize our profits. After that, we are aiming to introduce a new category of our energy drink into the market. Issues: our main issue is competition and this is why we should increase our marketing strategies to keep our brand image and to drive awayShow MoreRelatedRed Bull Marketing Plan2846 Words   |  12 PagesRed Bull Marketing Plan Introduction Red Bull, the iconic pioneer of the late 20th century energy drink movement, is enormously successful and popular. Everyone has had days where a cup of coffee seems woefully inadequate, and beverages such as Red Bull â€Å"give you wings†, as their slogan promises, and offer a refreshing lift to help people conquer their overfilled schedules and endless meetings. However, with only one flavor and a seemingly narrow target demographic, is Red Bull really capitalizingRead MoreRed Bull Marketing Plan7856 Words   |  32 PagesHow Red Bull woke up the teen market It looks (and tastes) like medicine, but it still conquered the soft drinks trade. Now the edgy pick-me-up is moving into the grown-up world of motor racing. John Arlidge reports reddit this John Arlidge The Observer, Sunday 5 December 2004 Article history At this time of year fallen leaves shroud the carefully planned suburbs of Milton Keynes. Mist drifts in from the fields. The posh car firms - Mercedes, Volkswagen, Audi - whose UK head offices ringRead MoreRed Bull s Marketing Plan1079 Words   |  5 Pagesworld of Red Bull, a world where anything is possible through high levels of caffeine consumption. Don’t believe wingsuiting down a mountain, parkouring the Grand Canyon or breaking the speed of sound while freefalling from the stratosphere is plausible? If rational and conventional thinking dictates everyday life then the answer is simply no. Although Red Bull strives to genuinely identify with consumers, the company endorses an idealistic world. The main focus of Red Bull’s marketing plan revolvesRead MoreMarketing Plan For Red Bull Gmbh3864 Words   |  16 PagesMARKETING PLAN: RED BULL Company Red Bull GmbH Brand/Product/Service: Red Bull Prepared by: Group 5A Anoop Kamboj I Deepak Tamak I Harshraj Pethraj Mehta I Amit Simant I Ranjit Kaur Chandel OVERVIEW Red Bull was introduced for the first time in 1987 by Dietrich Mateschitz in Austria. The launch of Red Bull gave birth to a whole new product category of energy drinks. It is sold in over 166 countries all over the world, and more than 40 billion cans have been sold till now. It uses the famousRead MoreDirect Marketing with Red Bull!1369 Words   |  6 PagesIntroduction How should Red Bull market its brand in the future? I think, although Red Bull has been extremely successful in the past, times have changed and the company and products should change with it, otherwise we probably lose market share to the tremendous increased number of competitors in no time.At the height of early mornings and late nights, Red Bull energy drink became the fuel of choice for people from all walks of life. So how is Red Bull marketing its brand to meet the changing needsRead MoreRed Bull Company Analysis1061 Words   |  5 PagesOrganizational Analysis Red Bull is an energy drink sold by Austrian company Red Bull GmbH, created in 1987. Red Bull is the most popular energy drink in the world, with 4.5 billion cans sold each year. Austrian entrepreneur Dietrich Mateschitz founded   Red Bull GmbH in a partnership with Chaleo Yoovidhya. After the product was introduced the consumption doubled year by year in Austria, so the company decided to introduce Red Bull in first foreign  markets. Those markets includedRead MoreRed Bulls Market1604 Words   |  7 PagesA Bull s Market - the marketing of Red Bull energy drink Red Bull, Austria s biggest export since Arnold Schwarzenegger, has methodically created and dominated the energy drink category much in the way players of the board game Risk would defeat their opponents. Dietrich Mateschitz, the owner of Red Bull International, created the highly caffeinated beverage in 1987. Five years later, the drink spread into neighboring countries like Hungary and Slovenia, followed by Germany and Switzerland.Read MoreRed Bull993 Words   |  4 PagesRed bull is the worlds oldest and most successful energy drink brands. In 1966, Red Bull was born in Thailand as a kind of vitamin energy drink, and then Austrian entrepreneur  Dietrich Mateschitz  was inspired by this pre-existing energy drink and took this idea, modified the ingredients to suit the tastes of westerners. Now it has more than 40 years of history so far with excellent quality and good reputation, Red Bull drinks are sold in more than 140 countries and regions around the world, rankRead MoreRe dbull Branding Strategy1207 Words   |  5 Pagestowards the purchase of intended products. Market segmentation is the basis for marketing strategy development. A company needs to design the right strategies to develop the relationships between its products to right consumers. Case section In terms of Red bull, the demographic and psychographic segmentation strategies are applied in their product design and branding approach. A key component of Red Bull’s global success is that it takes social variables into account on a global scaleRead MoreRed Bull: the Drink for Generation Y970 Words   |  4 Pages1. What is the marketing mix for Red Bull? What markets does Red Bull attempt to reach? How do marketing mix elements and target markets combine to form the firm’s marketing strategy? The marketing mix for Red Bull consists of the following: Product: Energy drink Price: $1.99 (premium) Distribution: Across clubs and similar outlets, mass merchandisers Marketing Communication: Word-of-mouth to television advertising Red Bull attempts to reach extremists, sports enthusiasts

Biomedical Science Focused on the Diagnosis and Therapy

Question: Compare the immunohistochemistry with next generation sequencing in regards to cholorectal cancer, in which biomarkers and other aspects are to be explained. The cases are present on an histology interface look through Patxl for the login details. navigate through the interface and the histology slides, and are to be screen captured in high quality, in the tabs on the left with noting for the scale and zoom, and be used as example to demonstrate points across. Answer: Summary This portfolio has been focused on the diagnosis and therapy of colorectal cancer with the consideration of patient case studies. In recent reports, it has noted by World Health Organization (WHO) that, there will be 1.477.402 new colorectal cancers in 2015, along with 752.731 deaths (Cunningham et al. 2014). In this portfolio, the diagnostic and therapeutic processes have been focused. The initial diagnosis with MRI and PET scan and final diagnosis with biopsies, H E, IHC and molecular testing has been discussed. In this portfolio, the importance of these diagnostic processes for determining the appropriate therapeutic combinations was discussed (Diaz et al. 2012). The genetic and molecular basis and origin of colorectal cancer as well as staging process has been discussed. Discussion The discussion is mainly based on colorectal cancer or colorectal adenocarcinoma. There are two patients, who are the major concern of this discussion. The immunohistochemistry and next generation sequencing is two important diagnostic tool and these are used for diagnosing the root or reason of colon cancer. The sequencing technologies are more advanced technologies and are very useful for identifying genetic mutations in signaling pathways by comparing with the wild-type genetic sequencing, thereby confirming cancer (Diaz-Rubio et al. 2012). The discussion will include the knowledge of the molecular basis of colorectal cancer development, therapeutic and prevention strategies with the use of example colorectal case studies. In the case scenario, two cases have been discussing. In one case, the patient is a 65 years old male patient had a change of his bowel habit as well as rectal bleeding. The patient had a history of prostate cancer. The patient was diagnosed with the adenocarcinoma and at his age, he is expected to develop colorectal cancer. It is because report suggested that, 95% of colorectal cancer occurs after 50 years of age (Kressner et al. 2011). The gastroenterologist examined the abdomen and performed a rectal examination that was found to be unremarkable. The purpose if the rectal examination was to ensure the origin of patients symptoms including changed bowel and rectal bleeding. It has been found that, 15% of colorectal cancers have a family history of inherited disease including adenomatosis polyps, Lynch syndrome, anal fissures etc. (Liao et al. 2012). Therefore, rectal examination helps to identify the origin of the disease symptoms. However, in this case, the patient might be subjected to radiotherapy for treating prostate cancer. Therefore, the mucosal lesion can be the caused due to irradiation. In the next stage, the CT scan was performed for more in-depth investigation. The scan found a tumor in recto-sigmoid colon along with a small-uncharacterized nodule in liver. After an initial diagnosis of the tumor through CT scan, the characteristic of tumor cells should be confirmed, whether the tumor is benign or malignant (Meyerhardt and Mayer 2011). For ensuring the nature of the tumor, the biopsy was done, as a final diagnosis of cancer. One technique for confirming the metastasis of malignant tissues is the PET scan and biopsy of the liver, thereby directing the way of management. The PET scan helps to provide information about the nature of liver nodule. In PET scan, no suspicious areas were identified, but the lesion appeared as hot. In PET scan, the areas that show hot have a tendency to consist malignant cells. Usually, the malignant cells can metabolize glucose faster than the normal cells and these areas appear as hot in PET scan. However, these are not a true indicator of malignancy. The liver nodule, in this case, appeared as hot'. Thus, to confirm the malignancy, MDT recommended liver biopsy based on morphology and lineage markers (Misale et al. 2012). The HE (haemotoxylin and eosin) test confirmed the malignant nature of liver nodule. Therefore, the liver nodule was a suspect for malignancy. The liver MRI is performed for characterizing the liver lesion. The MRI will also help to determine the respectability of the hepatic lesion; that is if the liver lesion is considered as resectable or not. In this scenario, the patient showed the resectable tumor . As the tumor identified as resectable, the resection of the primary tumor was recommended. Before resection, the tumor stage should be diagnosed as Dukes or TNM classification. The TNM staging system provides the evaluation of tumor involvement of nodes and organ metastasis. The patients tumor was identified to be in the stage pT3 N1 M1 (Schoen et al. 2012). The stage defined the nature of the malignant tumor and metastasis. T3 provides the information that cancer has grown through the whole colon or rectum wall; N1 provides the information that cancer has been found in 1-3 lymph nodes and M1 indicates cancer is found in the distant organ. Therefore, it can be said that, in this patient, the TNM classification indicated the metastasis of cancer. Another important diagnostic tool is immunohistochemistry with lineage biomarker assessment. For this patient, the CK antibodies those are the antibodies against keratins (K), were used as lineage biomarker (Scott et al. 2012). The keratins are filaments found in epithelial cells. There are 20 different keratins found and present as heterodimers including type A and type B. The presence of different types of keratin depends specifically upon the cellular lineage and composition of the tissue. The K7 is found to be expressed in biliary cells or liver. On the other hand, the K20 is expressed in the cells of the intestinal and gastric mucosa. Therefore, the immunohistochemistry is an important tool providing confirm an indication of metastasis if CK20 is found in liver biopsies that might be brought in the liver tissue through metastasis (Sinicrope and Sargent 2012). As the patien t had a history of prostate cancer, the presence of biomarker lineage PSA would also be tested. The negative CK20 provides evidence against the primary hepatocellular carcinoma. However, the presence of CDX2 was found that is highly specific for intestinal adenocarcinomas. Therefore, the immunohistochemistry found the origin of CRC as metastasis. Figure: Control (L) and Liver core Bx (IHC, CK 20) (Source: Sui et al. 2014) The doctor suggested the adjuvant therapy for this patient after the resection of the colon with hepatic metastasis. However, in the case of drug choice for targeted adjuvant therapy, molecular testing is important, for which the next generation sequencing is an efficient tool for identifying the genetic mutation, it identifies if the genes become active, missing or changed, undergoing a mutation. It is also important for selecting therapies based on the origin and nature of malignancy. The H E staining in biopsy is important for identifying morphological changes in tissue. The H E staining biopsy found the presence of invasive adenocarcinoma; the cancerous cells are found at the center (Tejpar et al. 2012). Figure: H E Staining: Rectosigmoid adenocarcinoma (Source: Vale et al. 2012) The classical adjuvant therapy of CRC metastasis includes 5-flurouracil (5-FU) and leucovorin along with oxaliplatin or irinotecan in a combination. More specific drug include the anti-epidermal growth factor receptor antibodies like panitumumab and cetuximab, anti-vascular endothelial growth factor-A antibody including bevacizumab and anti-angiogenic compounds like aflibercept and regorafenib (Vanneman et al. 2012). However, selection of drug is important for successful treatment that is based on evaluating the origin of cancer that can be confirmed with only molecular testing. The H E staining can confirm the tumor malignancy through its morphology and it cannot identify the molecular basis of cancer-based on which the therapy would be recommended, however, molecular testing is the most appropriate test for confirming the molecular origin of malignancy. Through next generation sequencing, the KRAS mutation was found in the patient. It is very important in therapy because, in KRAS and NRAS mutation, anti-EGFR drugs will not be applicable. Figure: Prognosis of Colorectal Cancer (Source: Watanabe et al. 2012) The Kras gene is a molecular switch when it is turned on; it activates the proteins necessary for the proliferation of receptors and growth factors signals including c-Raf and PI 3-kinase. It also upregulates glucose transporter, thus, the patient's lesion showed as hot' in PET scan. It is a proto-oncogene and a single amino acid substitution can transform the protein leading to malignancy. In this patient case, molecular testing revealed p. G12C (GlyCys) GGTTGT The gene is involved in the canonical pathway of CRC carcinogenesis including chromosome instability (Zauber et al. 2012). The kras helps to couple the EGFR with intracellular cascade, thereby activating the downward cascade and stimulates cell proliferation of colonic epithelium. In this pathway, the kras mutation activates the some downward signaling which causes rapid chromosomal gain or loss, while combined with inactivation of APC tumor-suppressor gene, thereby leading to aneuploidy or loss of heterozygosity. Figure: Next Generation Sequencing (NGS) testing for KRAS mutation (Source: Saltz et al. 2011) In some studies, it has been found that a protein of KRAS pathway, BRAF mutation also contributes in 5-10% CRC cases. BRAF and NRAS are two players in KRAS pathway and mutation of these genes activates RAS-RAF-MAPK pathways, downstream of EGFR. This is why NRAS and BRAF were tested for the case study patient (Saltz et al. 2011). Figure: Prognosis of Colorectal Cancer inn KRAS signaling pathway (Source: Zauber et al. 2012) The patient can be treated with Bevacizumab, an mAb targeting VEGF-A, an angiogenic factor, as the drug is a reliable therapeutic option for patients with RAS family mutation and therefore, it will be suitable for the case study patient. In addition, Regorafenib is a tyrosin kinase inhibitor that can block VEGF receptor and a third line treatment of mCRC. Therefore, these can be effective for the patient. The patient was treated with a combination of 5-fluorouracil, leucovorin and oxaliplatin. The in vitro animal and clinical studies provided showed that p53 is required for responding to 5-FU based chemotherapies. It study by Sui et al. (2014) provided the fact that; 5-FU causes aberrant autophagy in the p53 mutant cells. Research also showed that JNK activation as well as phosphorylation of Bcl-2 induces 5-FU induced autophagy. Bcl-2 is phosphorylated by p53mutation, thereby resulting in 5-FU resistance. This research has several impact upon the case study results. Figure: KRAS mutation and anti-EGFR therapy (Source: Sinicrope and Sargent 2012) In this case, the 65-years old patient failed to respond against the 5-FU, leucovorin and oxaliplatin and the malignant cells metastasized to liver and lung. It might be due to the simulations p53 mutation of cancerous tissue, thereby making those cells 5-FU resistant. Another case study, the patient is 75-years old female, who has prostate cancer in before. In this case, the patient has been diagnosed with Dukes A stage of colorectal carcinoma. According to the TNM classification, cancer has grown into a thick muscular layer of the colon or rectum and there was no spread in lymph nodes and no metastasis. Thus, no resection of the colon was needed. The histological staging found moderately differential adenocarcinoma (Meyerhardt and Mayer 2011). The patient was treated with 5-FU, leucovorin and oxaliplatin, but developed liver and lung metastasis. Therefore, this patient was also indicating the p53 mutation. Immunohistochemistry method for detecting p53 expression in the malignant tissue. The natural history of CRC should be understood for diagnostic and therapeutic approaches. Some genes are related to heredity like the genes of Axin2, POLD and TGFR2, inhibition of which predispose the risk of CRC (Iacopetta et al. 2013). Excessive red meat and alcohol consumption enhance the risk. Inflammatory bowel disease is another risk factor of CRC-related to heredity. However, according to the somatic mutation theory of cancer, cancer is caused by mutation of somatic cells, rather than germ cells through the nonlethal mutation related to the increased proliferation of mutant cells. There was no family history of cancer of the patient. Therefore, in the case scenario of 65-years old patient, radiation of colon during the treatment of prostate cancer might be the reason of KRAS mutation. Overview The major focus of the portfolio was to discuss the diagnostic and therapeutic measures of colorectal cancer. This portfolio helped to build sufficient understanding of the genetic and molecular mechanism of the origination of cancer and prognosis of cancer. The portfolio helped to develop knowledge on the particular diagnostic tools for the specific stage of cancer. The focus of this portfolio is colorectal cancer or adenocarcinoma (Kressner et al. 2011). The portfolio also highlighted the knowledge of cancer staging based on two tools, the TNM system and Dukes classification. The portfolio included the comparison of the histological and molecular diagnostic processes. For the patient, the primary diagnosis included the CT scan and rectal examination through PET scan (Diaz-Rubio et al. 2012). The patient was diagnosed with the rectosigmoid tumor. However, the final diagnosis was done with H E and IHC biopsy. These tests are reliable enough for determining the presence and morphological appearance of the tumor and malignancy. However, it has also been revealed that the molecular testing is important for confirming the origin of the malignancy. The MRI test helped in defining the lesion. The patient was also diagnosed with the small nodule in liver and PET scan was useful for indicating the risk of malignancy of that nodule. The HE confirmed the malignant tissue in that nodule. The patients tumor was resectable (Iacopetta 2013). At this point, it was revealed from the portfolio that the diagnosis is needed before resection of cancerous tissue to know the status of the tissue, whether the resection is suitable or not. However, the molecular testing is needed for identifying which gene is involved in the development of cancer and which internal pathway has been disturbed. It is important for selecting the correct therapeutic pathway. For molecular testing, the next generation sequencing was followed, KRAS, NRAS and BRAF were tested and a point mutation was found in KRAS gene sequence. This diagnostic finding directed the therapeutic pathway for the patient. The common anti-EGRF drugs are not applicable to the patients having this kind of mutation. Therefore, the portfolio highlighted the importance of molecular testing and H E testing over H E testing alone (Meyerhardt and Mayer 2011). The molecular biomarkers were also tested, like CK20 and CK7, as these markers are lineage specific and any abnormality in their location can indicate cancer occurrence. Therefore, these findings are also helpful in directing the cancer treatment. Besides the KRAS mutation, the importance of p53 mutation was also analyzed through this case study, as the patient failed to response the combined adjuvant therapy including 5-FU, thereby indicating the possibility of p53 m utation (Iacopetta et al. 2013). This portfolio analyzed another case study of a patient with moderately differentiated adenocarcinoma, for this patient no resection was recommended. At this point, the significance of staging process of cancer is revealed. From the study, new possible cancer therapies can be discussed including the therapies targeting cancer stem cells, some self-renewal pathways like Wnt, PTEN and Hedgehog with human monoclonal antibodies. However, it has been revealed that most of the CRCs originate from benign tumors, thus the focus of the research can also be diverted toward the development of new and more efficient screening procedures for early cancer detection (Cunningham et al. 2014). Reference List Cunningham, D., Humblet, Y., Siena, S., Khayat, D., Bleiberg, H., Santoro, A., Bets, D., Mueser, M., Harstrick, A., Verslype, C. and Chau, I., 2014. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.New England journal of medicine,351(4), pp.337-345. Diaz Jr, L.A., Williams, R.T., Wu, J., Kinde, I., Hecht, J.R., Berlin, J., Allen, B., Bozic, I., Reiter, J.G., Nowak, M.A. and Kinzler, K.W., 2012. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.Nature,486(7404), pp.537-540. Daz-Rubio, E., Gmez-Espaa, A., Massut, B., Sastre, J., Abad, A., Valladares, M., Rivera, F., Safont, M.J., de Prado, P.M., Galln, M. and Gonzlez, E., 2012. First-line XELOX plus bevacizumab followed by XELOX plus bevacizumab or single-agent bevacizumab as maintenance therapy in patients with metastatic colorectal cancer: the phase III MACRO TTD study.The oncologist,17(1), pp.15-25. Iacopetta, B., 2013. TP53 mutation in colorectal cancer.Human mutation,21(3), pp.271-276. Kressner, U., Ingans, M., Byding, S., Blikstad, I., Phlman, L., Glimelius, B. and Lindmark, G., 2011. Prognostic value of p53 genetic changes in colorectal cancer.Journal of clinical oncology,17(2), pp.593-593. Liao, X., Lochhead, P., Nishihara, R., Morikawa, T., Kuchiba, A., Yamauchi, M., Imamura, Y., Qian, Z.R., Baba, Y., Shima, K. and Sun, R., 2012. Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.New England Journal of Medicine,367(17), pp.1596-1606. Meyerhardt, J.A. and Mayer, R.J., 2011. Systemic therapy for colorectal cancer.New England Journal of Medicine,352(5), pp.476-487. Misale, S., Yaeger, R., Hobor, S., Scala, E., Janakiraman, M., Liska, D., Valtorta, E., Schiavo, R., Buscarino, M., Siravegna, G. and Bencardino, K., 2012. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer.Nature,486(7404), pp.532-536. Saltz, L.B., Cox, J.V., Blanke, C., Rosen, L.S., Fehrenbacher, L., Moore, M.J., Maroun, J.A., Ackland, S.P., Locker, P.K., Pirotta, N. and Elfring, G.L., 2011. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer.New England Journal of Medicine,343(13), pp.905-914. Schoen, R.E., Pinsky, P.F., Weissfeld, J.L., Yokochi, L.A., Church, T., Laiyemo, A.O., Bresalier, R., Andriole, G.L., Buys, S.S., Crawford, E.D. and Fouad, M.N., 2012. Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy.New England Journal of Medicine,366(25), pp.2345-2357. Scott, A.M., Wolchok, J.D. and Old, L.J., 2012. Antibody therapy of cancer.Nature Reviews Cancer,12(4), pp.278-287. Sinicrope, F.A. and Sargent, D.J., 2012. Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications.Clinical cancer research,18(6), pp.1506-1512. Sui, X., Kong, N., Wang, X., Fang, Y., Hu, X., Xu, Y., Chen, W., Wang, K., Li, D., Jin, W. and Lou, F., 2014. JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy.Scientific reports,4. Tejpar, S., Celik, I., Schlichting, M., Sartorius, U., Bokemeyer, C. and Van Cutsem, E., 2012. Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.Journal of Clinical Oncology,30(29), pp.3570-3577. Vale, C.L., Tierney, J.F., Fisher, D., Adams, R.A., Kaplan, R., Maughan, T.S., Parmar, M.K. and Meade, A.M., 2012. Does anti-EGFR therapy improve outcome in advanced colorectal cancer? A systematic review and meta-analysis.Cancer treatment reviews,38(6), pp.618-625. Vanneman, M. and Dranoff, G., 2012. Combining immunotherapy and targeted therapies in cancer treatment.Nature Reviews Cancer,12(4), pp.237-251. Watanabe, T., Itabashi, M., Shimada, Y., Tanaka, S., Ito, Y., Ajioka, Y., Hamaguchi, T., Hyodo, I., Igarashi, M., Ishida, H. and Ishiguro, M., 2012. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer.International journal of clinical oncology,17(1), pp.1-29. Zauber, A.G., Winawer, S.J., O'Brien, M.J., Lansdorp-Vogelaar, I., van Ballegooijen, M., Hankey, B.F., Shi, W., Bond, J.H., Schapiro, M., Panish, J.F. and Stewart, E.T., 2012. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.New England Journal of Medicine,366(8), pp.687-696.